Safety and Immunogenicity of a High Dosage Trivalent Influenza Vaccine among Elderly Subjects
Identifieur interne : 001361 ( Main/Exploration ); précédent : 001360; suivant : 001362Safety and Immunogenicity of a High Dosage Trivalent Influenza Vaccine among Elderly Subjects
Auteurs : Robert B. Couch [États-Unis] ; Patricia Winokur [États-Unis] ; Rebecca Brady [États-Unis] ; Robert Belshe [États-Unis] ; Wilbur H. Chen [États-Unis] ; Thomas R. Cate [États-Unis] ; Bryndis Sigurdardottir [États-Unis] ; Amy Hoeper [États-Unis] ; Irene L. Graham [États-Unis] ; Robert Edelman [États-Unis] ; Fenhua He [États-Unis] ; Diane Nino [États-Unis] ; Jose Capellan [États-Unis] ; Frederick L. Ruben [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2007.
Abstract
To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 µg of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15 µg of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only local pain and myalgias were significantly increased. The high dosage vaccine induced a higher frequency of serum antibody increases (≥4 fold) in both hemagglutination-inhibiting (HAI) and neutralization tests for all three vaccine viruses in the total group as well as subjects vaccinated and those not vaccinated the previous year. Mean titers of antibody attained, the magnitude of antibody increases and the frequencies of persons with final HAI antibody titers ≥1:32, ≥1:64, and ≥1:128 were all greater for the high dosage group in both serologic tests, for all groups, and for all vaccine viruses. These increased immune responses should provide increased protection against influenza in the elderly.
Url:
DOI: 10.1016/j.vaccine.2007.08.042
PubMed: 17913310
PubMed Central: 2243220
Affiliations:
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Chen</name><affiliation wicri:level="2"><nlm:aff id="A5">University of Maryland School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name><affiliation wicri:level="2"><nlm:aff id="A1">Baylor College of Medicine, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Sigurdardottir, Bryndis" sort="Sigurdardottir, Bryndis" uniqKey="Sigurdardottir B" first="Bryndis" last="Sigurdardottir">Bryndis Sigurdardottir</name><affiliation wicri:level="2"><nlm:aff id="A2">University of Iowa and VA Medical Center, Iowa City, IA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Iowa</region></placeName><wicri:cityArea>University of Iowa and VA Medical Center, Iowa City</wicri:cityArea></affiliation></author><author><name sortKey="Hoeper, Amy" sort="Hoeper, Amy" uniqKey="Hoeper A" first="Amy" last="Hoeper">Amy Hoeper</name><affiliation wicri:level="2"><nlm:aff id="A3">Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Cincinnati Children’s Hospital Medical Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Graham, Irene L" sort="Graham, Irene L" uniqKey="Graham I" first="Irene L." last="Graham">Irene L. Graham</name><affiliation wicri:level="2"><nlm:aff id="A4">Saint Louis University School of Medicine, St. Louis, MO</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Saint Louis University School of Medicine, St. Louis</wicri:cityArea></affiliation></author><author><name sortKey="Edelman, Robert" sort="Edelman, Robert" uniqKey="Edelman R" first="Robert" last="Edelman">Robert Edelman</name><affiliation wicri:level="2"><nlm:aff id="A5">University of Maryland School of Medicine, Baltimore, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="He, Fenhua" sort="He, Fenhua" uniqKey="He F" first="Fenhua" last="He">Fenhua He</name><affiliation wicri:level="2"><nlm:aff id="A6">Emmes Corporation, Rockville, MD</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Emmes Corporation, Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Nino, Diane" sort="Nino, Diane" uniqKey="Nino D" first="Diane" last="Nino">Diane Nino</name><affiliation wicri:level="2"><nlm:aff id="A1">Baylor College of Medicine, Houston, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Capellan, Jose" sort="Capellan, Jose" uniqKey="Capellan J" first="Jose" last="Capellan">Jose Capellan</name><affiliation wicri:level="2"><nlm:aff id="A7">Sanofi Pasteur, Swiftwater, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Sanofi Pasteur, Swiftwater</wicri:cityArea></affiliation></author><author><name sortKey="Ruben, Frederick L" sort="Ruben, Frederick L" uniqKey="Ruben F" first="Frederick L." last="Ruben">Frederick L. Ruben</name><affiliation wicri:level="2"><nlm:aff id="A7">Sanofi Pasteur, Swiftwater, PA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Sanofi Pasteur, Swiftwater</wicri:cityArea></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P14">To improve immune responses to influenza vaccine, a trivalent inactivated vaccine containing 60 µg of the HA of each component (A/H3N2, A/H1N1, B) was compared to a licensed vaccine containing 15 µg of the HA of each. More local and systemic reactions were reported by subjects given the high dosage but only local pain and myalgias were significantly increased. The high dosage vaccine induced a higher frequency of serum antibody increases (≥4 fold) in both hemagglutination-inhibiting (HAI) and neutralization tests for all three vaccine viruses in the total group as well as subjects vaccinated and those not vaccinated the previous year. Mean titers of antibody attained, the magnitude of antibody increases and the frequencies of persons with final HAI antibody titers ≥1:32, ≥1:64, and ≥1:128 were all greater for the high dosage group in both serologic tests, for all groups, and for all vaccine viruses. These increased immune responses should provide increased protection against influenza in the elderly.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li><li>Maryland</li><li>Missouri (État)</li><li>Ohio</li><li>Pennsylvanie</li><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Couch, Robert B" sort="Couch, Robert B" uniqKey="Couch R" first="Robert B." last="Couch">Robert B. Couch</name></region><name sortKey="Belshe, Robert" sort="Belshe, Robert" uniqKey="Belshe R" first="Robert" last="Belshe">Robert Belshe</name><name sortKey="Brady, Rebecca" sort="Brady, Rebecca" uniqKey="Brady R" first="Rebecca" last="Brady">Rebecca Brady</name><name sortKey="Capellan, Jose" sort="Capellan, Jose" uniqKey="Capellan J" first="Jose" last="Capellan">Jose Capellan</name><name sortKey="Cate, Thomas R" sort="Cate, Thomas R" uniqKey="Cate T" first="Thomas R." last="Cate">Thomas R. Cate</name><name sortKey="Chen, Wilbur H" sort="Chen, Wilbur H" uniqKey="Chen W" first="Wilbur H." last="Chen">Wilbur H. Chen</name><name sortKey="Edelman, Robert" sort="Edelman, Robert" uniqKey="Edelman R" first="Robert" last="Edelman">Robert Edelman</name><name sortKey="Graham, Irene L" sort="Graham, Irene L" uniqKey="Graham I" first="Irene L." last="Graham">Irene L. Graham</name><name sortKey="He, Fenhua" sort="He, Fenhua" uniqKey="He F" first="Fenhua" last="He">Fenhua He</name><name sortKey="Hoeper, Amy" sort="Hoeper, Amy" uniqKey="Hoeper A" first="Amy" last="Hoeper">Amy Hoeper</name><name sortKey="Nino, Diane" sort="Nino, Diane" uniqKey="Nino D" first="Diane" last="Nino">Diane Nino</name><name sortKey="Ruben, Frederick L" sort="Ruben, Frederick L" uniqKey="Ruben F" first="Frederick L." last="Ruben">Frederick L. Ruben</name><name sortKey="Sigurdardottir, Bryndis" sort="Sigurdardottir, Bryndis" uniqKey="Sigurdardottir B" first="Bryndis" last="Sigurdardottir">Bryndis Sigurdardottir</name><name sortKey="Winokur, Patricia" sort="Winokur, Patricia" uniqKey="Winokur P" first="Patricia" last="Winokur">Patricia Winokur</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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